The Last Judgment, 1536-1541 by Michelangelo, Sistine Chapel, Vatican.
Michelangelo and the Vatican butted heads over the nudity in this colossal fresco of the second coming of Christ and the apocalypse. All of the souls are being judged and either ascending to heaven or falling down into hell. Some of the figures are coming to grips with their fates based on how they lived they lives.