The Lamentation by Giotto di Bondone, Scrovegni Chapel, Padua.
The emotion and naturalism found in Giotto's 14th century frescos are among the reasons he is considered one of the founders of modern painting and his style paved the way for the artists of the Renaissance to follow. His understanding of space and the use of the landscape as a means to lead the viewer to the primary action in the scene, was revolutionary.